Asenova A., Ivanova S., Miteva V., Nedeva T., Moncheva P., Rasheva I.

Article Number: Acta Microbiol. Bulg. 2025; 41(04).

December 21, 2025

The initial colonization of the infant’s gastrointestinal tract is of paramount importance for their overall health, both early on and later in life. 

Mantovska, D.I., Zhiponova, M.K., Petrova, D., Alipieva, K., Bonchev, G., Boycheva, I., Evstatieva, Y., Nikolova, D., Tsacheva, I., Simova, S., Yordanova, Z.P.

Article Number: Plants, 2024, 13(1), 30

December 21, 2025

Stachys scardica Griseb. is a Balkan endemic species listed in The Red Data Book of Bulgaria with the conservation status “endangered”…

Milena Keremidarska-Markova, Veneta Evtimova-Koeva, Tsvetozar Penchev, Dilyana Doncheva-Stoimenova, Miroslava Zhiponova, Mariela Chichova and Bilyana Ilieva

Article Number: Life 2025, 15(12), 1938

December 18, 2025

Recently various plants have attracted considerable scientific interest as potential therapeutic alternatives to known drugs used in anti-inflammatory therapy…

Denev, P.; Pencheva, D.; Teneva, D.; Ognyanov, M.; Todorova, Z.

Article Number: Beverages 2025, 11, 176

December 11, 2025

Polyphenols and gamma-aminobutyric acid (GABA) are diet-derived bioactive compounds with distinct yet complementary health benefits…

Chorbadzhiev, P.; Gerginova, D.; Simova, S.

Article Number: Beverages 2025, 11, 169

December 1, 2025

Barley wine is one of the most chemically complex and historically significant beer styles, yet its molecular composition remains largely unknown…

Paunova-Krasteva, T.; Dimitrova, P.D.; Damyanova, Ts.; Borisova, D.; Leseva, M.; Uzunova, I.; Dimitrova, P.A.; Ivanova, V.; Trendafilova, A.; Veleva, R.; Topouzova-Hristova, T.

Article Number: Pharmaceuticals, 2025, 18, 1824

Pseudomonas aeruginosa is an opportunistic pathogen of high clinical relevance due to its ability to form biofilms, its inherent virulence regulated by quorum-sensing systems, and its multidrug resistance…

Veleva, R.; Kostadinova, A.; Trendafilova, A.; Ivanova, V.; Moskova-Doumanova, V.; Mladenova, K.; Doumanov, J.; Benkova, D.; Staneva, G.; Topouzova-Hristova, T.

Article Number: Membranes 2025, 15, 357

November 26, 2025

Interrelations between the plasma membrane and cytoskeleton are of crucial importance for essential cellular processes such as endocytosis, formation of intercellular junctions, cell morphology, etc…

N. Pagureva, F. Mustan, D. Cholakova, N. Burdzhiev, A. Ivanova, S. Tcholakova

Article Number: Colloids Surf. A 2026, 138915

Sugar esters, a class of surfactants derived from renewable resources, have attracted significant attention due to their biodegradability, low toxicity, and broad applications in food, cosmetic, and pharmaceutical formulations….

Aneta Lubenova and Petya Dimitrova-Mateva

Article Number: Forests 2025, 16 (11), p. 1701

November 7, 2025

The Common European ash (Fraxinus excelsior L.) is one of the main species constituting the field protection forest belts in Northeastern Bulgaria…

D. Gazolu-Rusanova, Z. Mitrinova, N. Pagureva, N. Burdzhiev, S. Tcholakova

Article Number: Journal of Molecular Liquids 2025, 440, 128844

Polysorbates are hydrophilic, nonionic surfactants widely used in food, cosmetic, and pharmaceutical products. Often, these emulsifiers are used in combination with different preservatives, and it is essential to conduct an indepth study of the influence of such additives on the properties of Polysorbate 60 solutions…

Viktoria Marinova-Yordanova, Yoana Kizheva, Iliyana Rasheva, Petya Hristova

Article Number: Journal of Chemical Technology and Metallurgy, 60, 6 2025, 961-977

November 2, 2025

The objective of this study were fifty strains of seven lactic acid bacteria (LAB) species (L. paracasei, L. casei, L. rhamnosus, L. plantarum, L. fermentum, L. delbrueckii subsp. bulgaricus and L. koreensis), previously isolated from various biotopes (human breast milk, newborn feces, and fermented vegetables)…

Priboyska, K.; Todorova, M.N.; Gerasimova, V.I.; Savova, M.S.; Krustanova, S.; Petkova, Z.; Stoyanov, S.; Popova, M.P.; Georgiev, M.I.; Alipieva, K.

Article Number: Molecules 2025, 30, 4202

Scrophularia aestivalis Griseb. is a Balkan endemic species whose phytochemical composition and medicinal properties have not been previously investigated…

Teneva, D.; Pencheva, D.; Teneva-Angelova, T.; Danova, S.; Atanasova, N.; Dobreva, L.; Ognyanov, M.; Petrova, A.; Slavchev, A.; Georgiev, V.; Denev, P.

Article Number:: Appl. Sci. 2025, 15, 10670

October 2, 2025

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate central nervous system, known for its role in promoting sleep, reducing anxiety, regulating blood pressure, and modulating stress, cognition, and behavior…

Vilhelmova-Ilieva, N.; Iliev, I.; Kamenova, K.; Grancharov, G.; Rusanov, K.; Atanassov, I.; Petrov, P.D.

Article Number: Biomedicines 2025, 13, 2417

Encapsulating essential oils in polymer-based nanocarriers can improve their stability, solubility, and bioavailability, while maintaining the biological activity of the oil’s active ingredients…

Kurteva, V.B.; Rusew, R.I.; Petkova, Z.S.; Angelova, M.; Shivachev, B.L.

Article Number: Molecules 2025, 30, 3811

September 19, 2025

Metal–organic frameworks (MOFs) are materials with extremely valuable properties. The latter depend largely on the ligand used; therefore, the design of new organic linkers is a priority task today…

Slavova-Kazakova, A.; Marcheva, M.; Taneva, S.; Momchilova, S

Article Number: Seeds 2025, 4, 38

Camelina (Camelina sativa L.) is a valuable source of seed oil, which contains above 30% of essential omega-3 fatty acid (alpha-linolenic acid, 18:3). On the one hand, this high content of linolenic acid is healthy and hence preferable, but on the other hand, highly unsaturated oils are easily deteriorated…

Miroslava Zhiponova, Grigor Zehirov, Krasimir Rusanov, Mila Rusanova, Miroslava Stefanova, Tsveta Ganeva, Momchil Paunov, Valentina Ganeva, Kiril Mishev, Petre I. Dobrev, Roberta Vaculíková, Václav Motyka, Zhenya Yordanova, Ganka Chaneva and Valya Vassileva

Article Number: Plants 2025, 14(15)

 July24, 2025

Light quality and duration profoundly influence the growth and productivity of plant species. This study investigated the effects of a blue–red LED light combination, known to induce flowering, on the physiological state and content of biologically active substances in catmint (Nepeta nuda L.) grown under controlled in vitro conditions….

Gerginova, D.; Staleva, S.; Petkova, Z.; Priboyska, K.; Chorbadzhiev, P.; Chimshirova, R.; Simova, S.

Article Number: Int. J. Mol. Sci. 2025, 26(14), 6993

Wild ales represent a diverse category of spontaneously fermented beers, influenced by complex microbial populations and variable ingredients. This study employed an integrated metabolomic profiling approach combining proton nuclear magnetic resonance (1H NMR) spectroscopy, liquid chromatography–mass spectrometry (LC-MS), and spectrophotometric assays (DPPH and FRAP) to characterize the molecular composition and antioxidant potential of 22 wild ales from six countries…

Nikolay Petkov , Petar Dorkov , Angel Ugrinov, Elzhana Encheva, Miroslav Abrashev, Diana Zasheva , Teodora Daneva and Ivayla N. Pantcheva

Article Number: Int. J. Mol. Sci. 2025, 26(13), 6504; 

July 5, 2025

In this study, we present the preparation and characterization of a novel thallium(I) coordination compound of the polyether ionophorous antibiotic salinomycin (SalH)…

Mila Rusanova, Krasimir Rusanov, Marina Alekova, Liliya Georgieva, Pavlina Georgieva, Tzvetelina Zagorcheva, Ivan Atanassov

Article Number: Applied Sciences 2025, 15(13), p.7334

We report the development of a procedure for ultrasound-assisted microscale extraction of metabolites from the flowers of Saint John’s wort (Hypericum perforatum L.), designed for comparative metabolite analysis of plants from genetic resource collections and natural and segregating populations…

Nikola Atanasov, Yana Evstatieva and Dilyana Nikolova

Article Number: Appl. Microbiol. 2025, 5, 60

June 29, 2025

The whole-genome sequencing of lactic acid bacteria provides a valuable resource for identifying the genetic determinants underlying molecular mechanisms related to their probiotic properties…

Dilek Gazolu-Rusanova, Marina Stoeva, Zlatina Mitrinova, Nevena Pagureva,Nikola Burdzhiev, Slavka Tcholakovа

Article Number: J. Molecular Liquids 2025, 434, 128069

Alkyl sarcosinates are amino acid-based anionic surfactants commonly used as primary surfactants in sulfate-free personal care products…

Veleva, R.; Topouzova-Hristova, T.; Kostadinova, A.; Benkova, D.; Trendafilova, A.; Ivanova, V.; Moskova-Doumanova, V.; Mladenova, K.; Doumanov, J.; Yordanova, V.; Staneva, G.

Article Number: Molecules 2025, 30, 2740

June 25, 2025

Oxidative stress induces lipid peroxidation within the membrane bilayer, thereby compromising membrane integrity…

Koleva, I.Z.; Kamenova, K.; Petrov, P.D.; Tzachev, C.T.

Article Number: Pharmaceuticals 2025, 18, 944

In this study, we present a green, scalable platform for the production of water-dispersible powders co-encapsulating the lipophilic bioactives curcumin (Cur) and eugenol (Eug) within the amphiphilic polymer Soluplus® (SP) via low-temperature spray drying.

Vanina Lozanova, Denitsa Teofanova, Bilyana Chakarova, Krasimir Rusanov, Kalina Pachedjieva, Anita Tosheva, Tzvetelina Zagorcheva, Lyuben Zagorchev

Article Number: Antioxidants 2025, 14(7), p.761

June 20, 2025

Dodders (Cuscuta spp.) are prominent parasitic plants widely known and exploited in traditional medicine…

Stancheva, R.; Damyanova, T.; Paunova-Krasteva, T.; Veleva, V.;Topouzova-Hristova, T.; Ivanova, V.; Trendafilova, A.; Dimitrov, I.;Rangelov, S.; Haladjova, E.

Article Number: Pharmaceutics 2025, 17, 800

Objectives: Nanosized polymeric micelles (PMs) with an average size of about 80 nm and moderately positive ζ potential, based on an amphiphilic poly(4-methyl-piperazin-1-yl)-propenone)-b-polylactide (PMPP-PLA) block copolymer, were prepared…

Stoyanova, N.; Damyanova, T.; Paunova-Krasteva, T.; Georgieva, A.; Toshkova, R.; Spasova, M.

Article Number: Molecules 2025, 30, 2307

May 24, 2025

Quercetin (QUE) is a bioactive flavonoid that is naturally present in various fruits and possesses many pharmacological activities…

Prancheva, A.; Kamenova, K.; Petrov, P. D.

Article Number: J. Polym. Sci. 2025, 63 (13), 2782-2794

This study is focused on developing novel nanocomplexes based on cationic polymeric micelles and the proteolytic enzyme serratiopeptidase (SER), coated with hyaluronic acid (HA)…

P. Chorbadzhiev, D. Gerginova, S. Simova

Article Number: Foods, 2025, 14, 1621

May 3, 2025

Wheat beers, including Witbier, Hefeweizen, and Weizenbock, are known for their unique sensory profiles, which are shaped by the combination of ingredients, fermentation conditions, and brewing methods…

Stoyanova, N.; Nachev, N.; Georgieva, A.; Toshkova, R.; Spasova, M.

Article Number: Pharmaceutics 2025, 17, 577

The plant extract of quercetin possesses valuable pharmacological properties. However, its high instability, poor water solubility, and low cell bioavailability has limited its medical applications…

T. Slavova, R. Stanimirova, K. Marinova, K. Danov

Article Number: Molecules 2025, 30(8), 1813

April 17, 2025

A systematic study on the mechanisms of cleansing artificial skin by solutions of widely used in personal care surfactants disodium laureth sulfosuccinate (DSLSS), sodium laureth sulfate (SLES), sodium dodecyl sulfate (SDS), dodecyl trimethyl ammonium bromide (DTAB), and coco glucoside (CG), is presented.

Bilyana Chakarova, Lyuben Zagorchev, Kalina Pachedjieva, Anita Tosheva, Tzvetelina Zagorcheva, Krasimir Rusanov, Denitsa Teofanova

Article Number: Plants, 14(8), p.1220

Holoparasitic plants of the genus Cuscuta are generally considered prominent agricultural pests. In addition to their negative economic effect on agriculture and their impact on natural plant societies, they have also been long known in East Asian as medicinal plants with beneficial properties…

D. Cholakova, N. Pagureva, M. Hristova, S. Tcholakova

Article Number: J. Colloid Interface Sci., 2025, 693,

April 15, 2025

At low electrolyte concentrations and pH ≳ 5, 0.5–5 wt% S970 dispersions exhibited low viscosities and behaved as freely flowing liquids. 

Georgieva, P., Rusanov, K., Rusanova, M., Kitanova, M. and Atanassov, I.

Article Number: International Journal of Molecular Sciences, 26(8), p.3705

In spite of the increasing industrial cultivation of lavender (Lavandula angustifolia Mill.), no genetic linkage map and mapping of QTLs (quantitative trait locus) has been reported for Lavandula species…

Stoilova, S.; Georgiev, G. L.; Mihaylova, R.; Kostova, B.; Petrov, P. D.

Article Number: Molecules 2025, 30, 1051

February 25, 2025

Aripiprazole (ARZ) is an atypical antipsychotic drug used to treat a variety of mood and psychotic disorders, such as schizophrenia, bipolar disorder, major depressive disorder, autism, and Tourette’s syndrome…

Z. Mitrinova, Z. Valkova, S. Tcholakova

Article Number: Colloids Surf. A 2025, 707, 135943, doi: 10.1016/j.colsurfa.2024.135943

The rheological response of surfactant solutions containing a mixture of anionic and zwitterionic surfactants, in the presence of shorter-chain cationic and nonionic co-surfactants…

Gerginova, D.; Chorbadzhiev, P.; Simova, S.

Article Number: Beverages 2025, 11, 29

February 17, 2025

The chemical profiles of young and mature wines produced from three grape varieties Merlot, Mavrud, and Sauvignon blanc were analyzed using 1H nuclear magnetic resonance (NMR) spectroscopy and advanced statistical methods…

Slavova-Kazakova, A., Taneva, S., Kamenova-Nacheva, M., Momchilova, S.

Article Number: C. R. Acad. Bulg. Sci., 2025, 78 (1), 27-35

Gamma-irradiation at doses of 10 kGy and 25 kGy was applied on walnuts in order to study changes in the fat yield, fatty acids composition, conjugated dienes and trienes, tocopherols and oxidative stability of the extracted glyceride oils…

P. Angelova, А. Hinkov, V. Gerasimova, P. Staleva, M. Kamenova-Nacheva, K. Alipieva, D. Shivachev, S. Shishkov, K. Shishkova

Article Number: Int. J. Mol. Sci., 2025, 26, 947

January 23, 2025

Recently, previously known viruses have changed their pathogenicity and encompassed new types of host populations…

V. Petkov, Z. Vinarov, S. Tcholakova

Article Number: Int. J. Pharm. 2024, 666, 124820, doi: 10.1016/j.ijpharm.2024.124820

Amorphous solid dispersions enhance the dissolution and oral bioavailability of poorly water-soluble drugs…

Hristo Penchev, Erik Dimitrov, Christo Novakov, Emi Haladjova, Ralitsa Veleva, Veselina Moskova-Doumanova, Tanya Topouzova-Hristova, Stanislav Rangelov,

Article Number: Polymers, vol:16, 2024, pages:3219-0,

November 20, 2024

Ladder oligomers containing calixarene skeletons in the main chain—calix[4]resorcinarene (CRA) ladder macromolecules with open chain and cyclic macromolecules with double ring-like (Noria-type) topologies—bring particular research attention as functional materials with various applications…

N. Pagureva, D. Cholakova, Z. Mitrinova, M. Hristova, N. Burdzhiev, S. Tcholakova

Article Number: J. Colloid Interface Sci. 2024, 674, 209-224, doi: 10.1016/j.jcis.2024.06.061

The underlying mechanism governing this unusual behavior is revealed and is shown to relate to the mono- to di-esters ratio in the solutions…

Krastev, V.; Stoyanova, N.; Valcheva, I.; Draganova, D.; Naydenov, M.; Spasova, M.; Stoilova, O.

Article Number: Polysaccharides 2024, 5, 698–714

November 7, 2024

Numerous bacterial species can both suppress plant pathogens and promote plant growth. By combining these bacteria with stabilizing substances, we can develop biological products with an extended shelf life, contributing to sustainable agriculture…

Taneva, S., Momchilova, S.

Article Number: Discover Food, 2024, 4: 112

Purslane (Portulaca oleracea L.) is a widespread weed plant used since ancient times as remedy and as food. Its seed oil possesses significant bioactive potential due to the high content of important phytonutrients, mainly essential fatty acids and phytosterols…

S. E. Todorova, R. I. Rusew, Z. S. Petkova, B. L. Shivachev, V. B. Kurteva

Article Number: Molecules, 2024, 29, 4906

October 16, 2024

Two series of polydentate N,O,S-ligands containing thiourea fragments attached to a p-cresol scaffold, unsymmetrical mono-acylated bis-amines and symmetrical bis-thioureas, are obtained by common experiments…

Kamenova, K., Iliev, I., Prancheva, A., Tuleshkov, P., Rusanov, K., Atanassov, I. and Petrov, P.D.,

Article Number: Gels, 10(10), p.627

Origanum vulgare ssp. hirtum essential oil (OEO) is a natural oil with high therapeutic potential. For some applications, however, the development of novel formulations is still needed to improve the bioavailability and stability of OEO…

Asenova A., Hristova H., Ivanova S., Miteva V., Zhivkova I., Moncheva P., Nedeva T., Marinova-Yordanova V., Hristova P., Rasheva I.,

Article Number: Microorganisms, vol:12, issue:9, 2024

September 5, 2024

During the last few decades, the main focus of numerous studies has been on the human breast milk microbiota and its influence on the infant intestinal microbiota and overall health…

Kamenova, K., Iliev, I., Prancheva, A., Tuleshkov, P., Rusanov, K., Atanassov, I. and Petrov, P.D.,

Article Number: Gels, 10(10), p.627

Origanum vulgare ssp. hirtum essential oil (OEO) is a natural oil with high therapeutic potential. For some applications, however, the development of novel formulations is still needed to improve the bioavailability and stability of OEO…

Anastasova, I., Ignatova, M., Manolova, N., Rashkov, I., Markova, N., Toshkova, R., Georgieva, A., Kamenova-Nacheva, M., Trendafilova, A., Ivanova, V. and Doncheva, T.

Article Number: Polymers, 2024, 16(15), 2105

July 24, 2024

The present study aimed to fabricate innovative fibrous materials with various biological activities from poly(3-hydroxybutyrate), sodium hyaluronate (HA), chitosan (Ch), Melissa officinalis (MO), Hypericum perforatum (HP) extract, or a combination of both extracts…

3. Sirine Jaber, Yana Evstatieva, Veronica Nemska, Dilyana Nikolova, Emilia Naydenova, Nelly Georgieva, Dancho Danalev,

Article Number: Current Research in Biotechnology, vol:8, 2024, pages:100236-0

Many microorganisms pose a threat to human health due to the ever-increasing bacterial resistance to conventional drugs. Nowadays, searching for new alternatives to conventional antibiotics to fight bacterial resistance is a main task….

Ivanova, V., Nedialkov, P., Dimitrova, P., Paunova-Krasteva, T. and Trendafilova, A.

Article Number: Pharmaceuticals, 2024, 17(7), 844

June 27, 2024

In this study, UHPLC-HRMS analysis of the defatted methanol extract obtained from Inula salicina L. led to the identification of 58 compounds—hydroxycinnamic and hydroxybenzoic acids and their glycosides, acylquinic and caffeoylhexaric acids, and flavonoids and their glycosides…

2. Zhiponova M, Yordanova Z, Zaharieva A, Ivanova L, Gašić U, Mišić D, Aničić N, Skorić M, Rusanov K, Chaneva G,

Article Number: Plant Physiol Biochem, issue:214, 2024, pages:108884-0

The phytohormones cytokinins are essential mediators of developmental and environmental signaling, primarily during cell division and endophytic interactions, among other processes…

Z. S. Petkova, R. I. Rusew, B. L. Shivachev, V. B. Kurteva

Article Number: Molecules, 2024, 29, 1938

April 24, 2024

A study on the functionalisation of 2-mercapto-5-methyl-1,3,4-thiadiazole has been conducted, yielding two series of products: 2-(ω-haloalkylthio)thiadiazoles and symmetrical bis-thiadiazoles, with variable chain lengths…

Durão, R. M.; Marinova, M. K.; Ravutsov, M. A.; Simeonov, S. P.

Article Number: Sustain. Chem. Pharm. 2024, 39

Diversification of the furanic platform has been developed from 4-ketovalerolactone (KVL), a platform molecule readily available from furfuryl alcohol…

Trusheva, B., Petkov, H., Chimshirova, R., Popova, M., Dimitrova, L., Zaharieva, M. M., Ilieva, Y., Vasileva, B., Tsvetkova, I., Najdenski, H., Miloshev, G., Georgieva, M., Bankova, V.

Article Number: Heliyon, 10(7), 2024, e28621

March 25, 2024

Natural deep eutectic solvents (NADESs) have been considered promising to replace traditional volatile and toxic organic solvents for the extraction of biologically active substances from natural sources…

5. Asenova, A., Hristova, H., Nedeva, T., Hristova, P., Zhivkova, I. and Rasheva, I.

Article Number: IOP Conference Series: Earth and Environmental Science (Vol. 1305, No. 1, p. 012015)

The low pH is considered a protective mechanism of the body against infections byproviding unfavourable conditions for their causers. Analysis of fecal pH of newborns havebeen performed around the world during the last century, and a disturbing tendency has beensurveilled due to industrialization and lifestyle change of mothers and their babies…

4. Ivanov G, Kercheva A, Tosheva A, Yordanova Z, Zhiponova M,

Article Number: In IOP Conference Series: Earth and Environmental Science (Vol. 1305, No. 1, p. 012003)

February 1, 2024

Plantago atrata Hoppe (dark plantain; Plantaginaceae) is a lesser-studied narrow-leaved Plantain species and in the present review, we summarize the knowledge about the plant…

D. Cholakova, M. Pantov, S. Tcholakova, N. Denkov

Article Number: Crystal Growth Des. 2024, 24, 362 – 377, doi: 10.1021/acs.cgd.3c01088

Crystallization of alkane mixtures has been studied extensively for decades. However, the majority of the available data consider the behavior of alkanes with chain length of 21 C atoms or more…

Mantovska DI, Zhiponova MK, Petrova D, Alipieva K, Bonchev B, Boycheva I, Evstatieva Y, Nikolova D, Tsacheva I, Yordanova Z,

Article Number: Plants MDPI, vol:13, issue:1, 2024, pages:30-0

January 1, 2024

Stachys scardica Griseb. is a Balkan endemic species listed in The Red Data Book of Bulgaria with the conservation status “endangered”…